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University of Sussex
Research Fellow in White Matter Ultrastructure and Electrophysiological Changes in cSVD Ref: 43916 (Fixed Term)
Brighton On-site 2-5 yrs exp
Glial BiologyOligodendrocyte BiologyWhite Matter ResearchRodent ModelsWhole-cell Patch-clamp Electrophysiology
Requirements
Candidates should hold or be nearing completion of a PhD in neuroscience, physiology, cell biology, or a related field. Experience in rodent models, electrophysiology, and advanced microscopy is highly desired along with a strong publication record.
Job Description
About The Role
We are seeking a highly motivated Research Fellow to join an exciting programme investigating the mechanisms underlying white matter injury caused by chronic cerebral hypoperfusion and hypoxia. The successful candidate will contribute to research aimed at understanding how glial cells, particularly oligodendrocytes, respond to vascular insufficiency and how these responses contribute to demyelination, remyelination failure and cognitive impairment.
The project combines in vivo disease models with advanced cellular and molecular approaches, including electrophysiology, high-resolution imaging, molecular biology and ultrastructural analysis. The successful candidate will work within a collaborative and interdisciplinary research environment and will have opportunities to develop independent research, publish in leading journals, present findings at international conferences and contribute to future grant applications.
About You
You will hold (or be close to completing) a PhD in neuroscience, physiology, cell biology or a related discipline.
You should have experience in several of the following areas:
About Our School
Our Psychology school has a rich history extending over half-a-century, marked from the start by our variety of research and courses. From the ground-breaking work of scholars such as Stuart Sutherland and Marie Jahoda, we've grown to cover all areas of psychology.
The School was formally established in 2009, bringing together academics across biological, cognitive, developmental, clinical and social psychology into one School. We've now entered the second decade of our existence as one of the largest and most influential academic communities for psychology in the country!
Anchored by our core values of kindness, integrity, inclusion, collaboration and courage, our research and teaching address societal challenges to create a better world.
Please find further information regarding the School of Psychology.
The School of Psychology is proud to hold a Silver Athena Swan Award.
Why work here
Our university is situated off the A27, next to the beautiful South Downs where you will enjoy everything that our 150-acre campus has to offer. We are accessible by public transport; Falmer train station is a five-minute walk to campus and several bus stops are located within campus. We also have dedicated cycling paths and encourage our staff to use these with our offering of a cycle to work scheme.
Sussex is a renowned, multi-accredited, research-led International University and this is only possible because of the people that work here. Whether you are a member of Faculty, part of a Professional Services team or a Student, it’s our people that make us great and we want you to be part of that.
Find Out More About Our Reward And Benefits Package.
Find out about our equality, diversity and inclusion.
Further Key Information
Please contact Catherine Hall (Catherine.Hall@sussex.ac.uk) for informal enquiries.
The University of Sussex values the diversity of its staff and students, and we welcome applicants from all backgrounds.
Eligibility
Visa Sponsorship Queries: This role has been assigned an eligible SOC code and meets the salary requirements for Skilled Worker Sponsorship if full time and appointed at Grade 7.4. Please consult our Skilled Worker Visa information page for further information about Visa Sponsorship.
The University requires that work undertaken for the University is performed in the UK.
We are seeking a highly motivated Research Fellow to join an exciting programme investigating the mechanisms underlying white matter injury caused by chronic cerebral hypoperfusion and hypoxia. The successful candidate will contribute to research aimed at understanding how glial cells, particularly oligodendrocytes, respond to vascular insufficiency and how these responses contribute to demyelination, remyelination failure and cognitive impairment.
The project combines in vivo disease models with advanced cellular and molecular approaches, including electrophysiology, high-resolution imaging, molecular biology and ultrastructural analysis. The successful candidate will work within a collaborative and interdisciplinary research environment and will have opportunities to develop independent research, publish in leading journals, present findings at international conferences and contribute to future grant applications.
About You
You will hold (or be close to completing) a PhD in neuroscience, physiology, cell biology or a related discipline.
You should have experience in several of the following areas:
- glial biology, oligodendrocyte biology or white matter research
- rodent models of neurological disease
- whole-cell patch-clamp electrophysiology
- calcium imaging
- confocal and fluorescence microscopy
- immunohistochemistry and quantitative image analysis
- molecular cloning and viral vector design
- stereotaxic surgery and viral delivery
- primary neural cell culture and organotypic slice culture
- transmission electron microscopy
- statistical analysis of biological data
About Our School
Our Psychology school has a rich history extending over half-a-century, marked from the start by our variety of research and courses. From the ground-breaking work of scholars such as Stuart Sutherland and Marie Jahoda, we've grown to cover all areas of psychology.
The School was formally established in 2009, bringing together academics across biological, cognitive, developmental, clinical and social psychology into one School. We've now entered the second decade of our existence as one of the largest and most influential academic communities for psychology in the country!
Anchored by our core values of kindness, integrity, inclusion, collaboration and courage, our research and teaching address societal challenges to create a better world.
Please find further information regarding the School of Psychology.
The School of Psychology is proud to hold a Silver Athena Swan Award.
Why work here
Our university is situated off the A27, next to the beautiful South Downs where you will enjoy everything that our 150-acre campus has to offer. We are accessible by public transport; Falmer train station is a five-minute walk to campus and several bus stops are located within campus. We also have dedicated cycling paths and encourage our staff to use these with our offering of a cycle to work scheme.
Sussex is a renowned, multi-accredited, research-led International University and this is only possible because of the people that work here. Whether you are a member of Faculty, part of a Professional Services team or a Student, it’s our people that make us great and we want you to be part of that.
Find Out More About Our Reward And Benefits Package.
Find out about our equality, diversity and inclusion.
Further Key Information
Please contact Catherine Hall (Catherine.Hall@sussex.ac.uk) for informal enquiries.
The University of Sussex values the diversity of its staff and students, and we welcome applicants from all backgrounds.
Eligibility
Visa Sponsorship Queries: This role has been assigned an eligible SOC code and meets the salary requirements for Skilled Worker Sponsorship if full time and appointed at Grade 7.4. Please consult our Skilled Worker Visa information page for further information about Visa Sponsorship.
The University requires that work undertaken for the University is performed in the UK.
Education
Postgraduate Degree
Skills
Glial BiologyOligodendrocyte BiologyWhite Matter ResearchRodent ModelsWhole-cell Patch-clamp ElectrophysiologyCalcium ImagingConfocal MicroscopyFluorescence MicroscopyImmunohistochemistryQuantitative Image AnalysisMolecular CloningViral Vector DesignStereotaxic SurgeryPrimary Neural Cell CultureTransmission Electron MicroscopyStatistical Analysis